What is the difference between IR and EMS in horses?
Insulin resistance (IR) and Equine Metabolic Syndrome (EMS) are two related, but different, conditions in horses. Both diseases involve a disturbed metabolism and excess weight. To help your horse properly, it is important to know exactly what is going on.
Insulin resistance
Diseases

31 March '25 • 1 min reading time
What is Insulin Resistance (IR)?
Insulin resistance is a condition in which a horse's cells become less sensitive to the hormone insulin. This means that the body becomes less efficient at absorbing glucose from the blood. Since the glucose is no longer properly removed from the blood, blood sugar levels increase. As a result, the horse has more difficulty maintaining balanced blood sugar levels. The primary cause of insulin resistance is overweight. When a horse receives more feed or a diet higher in sugar than necessary, it can lead to weight gain and eventually IR. A diet containing too much sugar and starch, combined with too little exercise, can contribute to the development of insulin resistance. This can lead to laminitis. Common signs include a thickened crest or fat deposits on either side of the tail. The excess sugars that horses consume do not only come from concentrated feed but also from sugar-rich grass.
What is Equine Metabolic Syndrome (EMS)?
EMS is a complex syndrome characterized by a combination of overweight, insulin resistance, and laminitis. IR is, therefore, a part of EMS. In the Netherlands, approximately 55% of leisure horses are overweight. Due to excess weight, these horses often perform less effectively and may struggle to regulate their body temperature. An overweight horse can become insulin resistant (IR), and obese horses may also develop a disrupted fat metabolism. This happens in horses with EMS, as their entire metabolism and hormone balance are affected by obesity. Horses with EMS are also at a higher risk of developing laminitis. A horse with EMS will have noticeable excess weight, with fat deposits clearly visible, for example, on the neck. The syndrome can result from genetic predisposition or from an overly rich diet with too much sugar and insufficient physical activity. In most cases, it is a combination of these factors. EMS is a serious condition that requires action. The most important aspect is to prevent your horse from becoming overweight or to work towards healthy weight loss. Proper feeding management and sufficient exercise are crucial in this regard.